The is on track for its best weekly gain since July, up about 3 percent, but if history is any indication, those gains may evaporate on Monday.
Mondays have been a tough day for stocks this year with indexes closing negative over 67 percent of the time, and after a Good Friday, stocks still may not find a relief.
Historically, U.S. stocks tend to trade down on the Monday following a Good Friday, with the NASDAQ Composite leading the biggest decline.
Since the inception of NASDAQ in 1971, the index posted a loss over 62 percent of the time, down on average 0.33 percent.
Other major indexes—the Dow and S&P 500 also followed suite with losses over 55 percent of the time on Monday following the holiday.
On a positive note, stocks tend to trade up the week after.
Not surprisingly, NASDAQ has led the market with gains over half a percent while the Dow and S&P followed with modest gains over 0.20 percent.
The markets have been closed now for more than 100 years since the last time they opened on Good Friday in 1907.
Here's a look at how indexes performed the week after the observance of this religious holiday in the last 14 years:
—By CNBC's Pradip Sigdyal