"It's nice to have a day job again," said Adams. "'Dilbert' was born when I was working in the big company environment and that was fertile ground for material."
He is now leaning on his experience building a company as new material for the cartoon.
"You can build anything, but what you don't know is what people respond to," Adams said of the trial and error nature of finding success in the Valley.
He said entrepreneurs must take on a systems-oriented approach and move away from setting definitive goals. This strategy, referred to as the "pivot," is a technique that's brought incredible success to many companies.
Take eBay, for instance, Adams said. It began as a forum for Pez aficionados to trade the candy dispensers. Now, it's a $62 billion e-commerce giant where you can buy or sell anything from a Canadian Maple Leaf coin to a Lamborghini.