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The book, "Blood Feud" by Edward Klein, claims Clinton's comments took place at a May 2013 dinner with college friends in Westchester, the New York Post reported.
"When her friends asked Hillary to tell them what she thought — really thought — about the president she had served for four draining years, she lit into Obama with a passion that surprised them all," Klein wrote, according to the Post.
The book quoted Clinton as adding: "The thing with Obama is that he can't be bothered, and there is no hand on the tiller half the time. That's the story of the Obama presidency. No hand on the f–king tiller."
Clinton also addressed specific Obama scandals, according to the book.
"The IRS targeting the Tea Party, the Justice Department's seizure of AP phone records and [Fox reporter] James Rosen's e-mails — all these scandals. Obama's allowed his hatred for his enemies to screw him the way Nixon did," the Post quoted the book as saying.
Clinton served as Obama's Secretary of State until February 2013.
—By CNBC staff