'Kashing in' on the Kardashian klout

It's an impossible trio to ignore. Even if you don't seek out the latest news on the Kardashian sisters, it finds you.

Kim, Kourtney and Khloe Kardashians' wide-reaching collective influence is powerful and—as a number of companies and brands hope—profitable.

"We're all about empowering other women to be successful, and we encourage our little sisters to work hard and be successful," Kim Kardashian said in an interview with CNBC.

"We love fashion and beauty, and that's who we are and what we work towards."

While the family initially burst onto the celebrity spotlight in controversial ways, from father Robert Kardashian's role as one of O.J. Simpson's defense attorneys to daughter Kim's sex tape, their rise to fame has been nearly unparalleled.

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Forbes recently ranked Kim Kardashian No. 80 on its Celebrity 100 list, estimating the reality star pulled in more than $28 million over the past 12 months.

Between product endorsements, product lines, websites, games and TV shows over the past several years there's hardly a category the sisters haven't touched. From Sears to Skechers, from QuickTrim to Shoedazzle.com, from cosmetics lines to mobile games, and now Babies R Us, the Kardashian influence is seemingly everywhere.

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The Kardashians spoke with "Closing Bell" about the latest edition of their Kardashian Kids clothing line at retailer Babies R Us Monday afternoon in New York City.

"We were really wanting to bring fashion and high fashion to a baby's line but still keep it really affordable," Kim said. "Now since I've had my baby, I really understand how important it is to have pieces that are extremely functional."

While Kim Kardashian's husband, Kanye West, may be slightly biased in his assessment that his wife is more influential than even the first lady of the United States, it's difficult to argue with her social media profile. Add in Khloe, Kourtney and half sisters Kendall and Kylie, and the family's reach is a dream come true for any brand.

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"We only take on projects that we're really passionate about," Kourtney said. "We always say we are a brand for our fans because through social media we're so lucky to see what people are asking us for, what they're looking for and so we really design what we like but also take our fans in mind."

Kim has nearly 22 million followers on Twitter. (To put this in perspective, Beyonce Knowles has 13.4 million.) Kourtney has an impressive 12.1 million Twitter followers and Khloe has more than 10.1 million. On Facebook's Instagram, Kim's profile has nearly 16 million followers. On Sunday Kim posted a close-up picture of herself flashing her engagement ring with the hashtag "#goodmorning" and it got more than 622,000 "likes."

Is it possible to have too many product endorsements or partnerships in their empire? Kim said the sisters are careful about protecting their brand.

"Last year we really re-evaluated what our brand is and what it stands for and we stopped putting our name on things. We really wanted to only be involved in ...things we're extremely passionate about and something that we own," Kim said.

Having children, she said, caused her to re-prioritize her life. However, she disagreed with PepsiCo CEO Indra Nooyi's comments that women can't have it all.

"That's just not like a positive outlook. For me, like, my mom taught us girls we could have it all," Kim said.

—By CNBC's Courtney Reagan; Michelle Fox contributed to this report.