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Voters went to the polls Thursday to decide whether Scotland should be independent after being part of the U.K. for more than 300 years. Results are expected overnight into Friday.
Farage, who is in favor of Scotland staying part of Great Britain, thinks the "no" vote on independence will win, but said he expects a big constitutional change.
"After this very, very contentious campaign, I don't think anything in the U.K. will ever quite ever be the same again," he said.
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Farage is no stranger to controversy. His critics have accused him of stirring up a lot of British anti-European feeling that is tearing apart society. However, he dismissed any comparison to the Scottish Independence Party's leader, Alex Salmond.
"If any of my supporters had behaved as Alex Salmond's had, I would be the biggest pariah ever seen in this country," he said. "We love Europe. What we don't love is the European Union. … We want to be free."
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He also called Salmond a "false prophet" for wanting to ditch the U.K. for Europe.
"Actually he doesn't want to be independent all. He wants Scotland to be a province of a new European state," he said, adding that if the yes vote wins, Salmond would have no option but to sign up for the euro and have "very little independence at all."
—By CNBC's Michelle Fox