"This is something Mark really cares about and that Facebook really cares about as well," said Naomi Gleit, Facebook's vice president of product management.
This isn't the first time Facebook has made charitable giving as easy as a click of a "donate" button.
After Typhoon Haiyan hit the Philippines, Facebook launched a "Donate Now" initiative that made it easier for people to donate to those affected by the storm.
Read MorePaul Allen pledges $100 million to fight Ebola
And Facebook was the platform that gave rise to the Ice Bucket Challenge viral fundraising phenomenon which raised $115 million and awareness for ALS, commonly known as Lou Gehrig's disease. More than 10 billion ice bucket videos were viewed by 440 million people around the world on Facebook.
According to nonprofits working on the ground in West Africa, fundraising for Ebola has been slow to take off.
Three months after the Haiti earthquake, more than 8,000 people had made a donation in support of International Medical Corps' efforts there, after the earthquake in Japan, more than 10,000. But three months into raising funds for Ebola, only 824 people have given money, the nonprofit says.
Large gifts from individuals have made the biggest contributions to fighting the Ebola epidemic so far. Zuckerberg and his wife Priscilla Chan gave $25 million to the foundation that funnels private donations to the Centers for Disease Control.
The Bill and Melinda Gates Foundation has pledged $50 million starting with contributions to the CDC, the World Health Organization and Unicef. Paul Allen, who helped found Microsoft with Gates, has promised $12.9 million to the CDC and $2.8 million to the American Red Cross.