Authorities say the driver lost control of the double-trailer and went off the right side of the road, then went down a grass median and ended up on an exit ramp.
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The driver, whose name was not released, was treated for minor injuries.
FedEx officials say company crews responded to the scene shortly after the crash occurred and quickly reloaded packages to help reduce possible delivery delays.
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The accident occurred on a day that FedEx says is typically their busiest day of the year.