Additionally, Cramer finds the topic of interest rates to be an important one. There is just too much hand-wringing about what she will do. Will she raise them? Will she follow Jim Cramer's advice and sell those huge bonds from her inventory?
Frankly, there are just too many significant repercussions of raising interest rates right now. The emerging markets are watching her every move. If the Fed raises rates, Cramer thinks money will come pouring out of those markets into ours.
Additionally, this would be terrible timing for Europe. Central banker Mario Draghi is doing everything in his power to jumpstart the European economy right now, including taking on tons of debt. A rise in rates would raise the value of the dollar, and cause a huge amount of instability for a continent that is already unstable.
Then there is an entirely different group that bothers Cramer most. The Fed haters and their never-ending complaints about Yellen.
These haters tend to be people who are so rich and are afraid their purchasing power will be reduced, and want more safe income to satisfy themselves. Or they are investors who are short bonds and stocks and are betting against the Fed.
"Oh, and shut up, and disclose your real positions including your shorts and your underinvested status. Then, at least, you can be taken at face value unlike now where I just see you as selfish promoting ministers of your own portfolio," he added.
Please Yellen. Save Cramer from taking down the wrath of the Fed haters, and don't raise rates.
Read More Cramer's tellin' Yellen, don't raise rates
Cramer has always said that he loves biotech stocks. It doesn't matter if oil is up or down, this sector can rally even when the rest of the market is down.
That is why Cramer is always looking for the next big biotech stock, so that investors can have massive multi-year gains. And boy, does he have a hot one up his sleeve; Isis Pharmaceuticals.
Isis has an amazing pipeline, especially its drug FXI that was created as an antithrombotic to prevent blood clots.
The reason why this drug is revolutionary is because most drugs that prevent blood clots have some serious side effects. One of these is an increased risk of bleeding. So if you were to go in for surgery and you took an anticoagulant, you run a risk of bleeding out during surgery, which is a scary proposition for the surgeon and patient.
"The issue is important to me because my dad, who passed away last month, had a stroke a couple of years ago, and when they did his ablation surgery they have him Coumadin which would have caused him to bleed to death pretty rapidly if he'd been alone," Cramer said.
That is why FXI is a big deal. It has the ability to prevent blood clots while causing much less bleeding. There is no other drug on the market currently that can address both of these issues.
Read MoreCramer: Watch out Regeneron, here comes Isis Pharma