Cramer: Greece situation unlike the old days

Investors should not fret much over the latest impasse between Greece and the euro zone, CNBC's Jim Cramer said Tuesday.

"This is not like the old days," Cramer said on CNBC's "Squawk on the Street." "Spain is very strong, Italy was a standout for retail sales, so we're not where we were, and I think Greece can be isolated."

Cramer made his remarks after talks between Greece and euro zone finance ministers stalled Monday, driving U.S. stocks lower Tuesday morning.

Read MoreUS stocks trade lower; Greece debt talks eyed

(Click here to see what U.S. markets are doing)

European stocks were mixed Tuesday.

Cramer said investors shouldn't focus on Greece. "It's not going to be resolved this week, and it's also not going to bring us debt," he said. "I think the talks are about who is going to blink."