Coronado Biosciences In-Licenses IV Tramadol, a Phase III Ready Asset, From Revogenex Ireland Ltd.

NEW YORK, Feb. 18, 2015 (GLOBE NEWSWIRE) -- Coronado Biosciences, Inc. (Nasdaq:CNDO) has obtained an exclusive license to an intravenous (IV) formulation of tramadol for the U.S. market from Revogenex Ireland Ltd., a privately held company in Dublin, Ireland. Coronado has formed a wholly owned subsidiary, Avenue Therapeutics, Inc., to acquire, in-license, develop and commercialize products principally for use in the U.S. hospital market. Coronado will transfer the Revogenex license to Avenue Therapeutics, Inc. In addition to IV tramadol, Avenue Therapeutics plans to seek additional products.

Dr. Lindsay A. Rosenwald, Coronado's Chairman, President and CEO, said, "Forming this subsidiary that focuses on hospital-based products is a further step in our strategy to diversify our business. We believe that IV tramadol fills an important unmet need in the acute care setting."

Dr. Jeffrey Ping Chairman, CEO and Co-Founder of Revogenex, said, "IV Tramadol represents the first of many products we are developing, and we look forward to the successful partnership with Coronado to introduce IV Tramadol into the U.S. market."

Tramadol is a centrally acting synthetic opioid analgesic for moderate to moderately severe pain. It is available as immediate release or extended-release tablets in the U.S. It has been reported that oral tramadol sales were approximately $1.2 billion in the U.S. in 2014.

Avenue Therapeutics plans to initiate a Phase III development program of IV tramadol for the management of post-operative pain later this year. Under the terms of the agreement, Coronado and Avenue Therapeutics will assume sole responsibility for the development and commercialization of IV tramadol in the U.S. Revogenex received an upfront payment of $2 million upon execution of the exclusive license and is eligible to receive additional milestone payments upon the achievement of certain development milestones, in addition to royalty payments for sales of the product.

Torreya Partners represented Revogenex as an advisor for the transaction.

About Coronado Biosciences

Coronado Biosciences is a biopharmaceutical company dedicated to investing in, acquiring, developing and commercializing novel pharmaceutical products. The Company's portfolio currently includes novel immunotherapy agents for the treatment of autoimmune diseases and cancer. As part of its growth strategy, the company plans to leverage its biopharmaceutical business and drug development expertise to acquire rights to, or to finance, innovative pharmaceutical and biotechnology products, technologies and/or companies, using a variety of approaches including licensing, partnerships, joint ventures, direct financings and/or public and private spin-outs. For more information, visit

About Revogenex

Revogenex is a pharmaceutical product development company specializing in high-speed global development of products that address unmet patient needs using its global capabilities and relationships. Revogenex has been funded to date by Dr. Ping together with Greater Pacific Capital. For more information, visit and

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CONTACT: Lucy Lu, MD Executive Vice President & Chief Financial Officer Coronado Biosciences, Inc. 781-652-4525; ir@coronadobio.comSource:Coronado Biosciences, Inc.