Believe it or not, when "Mad Money" first came on the air a decade ago, Cramer had a hard time getting executives to appear on the show.
The very first CEO interview was with Dr. Len Schliefer, who was at the time the CEO of a small development stage biotech company called Regeneron.
At the time the stock traded just above $4, and as of Monday it closed at $426. Cramer gave this stock his blessing for speculation, and the company turned out to be one of the best blessings he has ever given. Its cholesterol drug has been a big hit, and Cramer thinks it could bring the stock even higher.
Could the company foresee that it would be so profitable? Cramer sat down with Dr. Schliefer 10 years later to find out.
"The thing about this business is that it's all based on what you do for patients. This is not the soap business or the detergent business where the marketing clout matters. The bottom line is if you come out with a product that makes a difference for patients you're going to sell the product, patients are going to do better and your investors and shareholders are going to profit as well," Schleifer said.
After Monday's big Apple Watch reveal, Jim Cramer is still sticking to his guns—just own Apple, don't trade it!
For those who were waiting for this snazzy device to be revealed and decided to trade the stock based on the Apple Watch, they were burned. All day the stock climbed in anticipation for the device, and even ran up almost $3.
Then investors found out that there is only an 18-hour battery life before it dies, and the stock started to plummet. Meaning, those who bought Apple stock just for the trade on the watch were playing with fire.
"Trading Apple is a fool's game because of the lack of short-term information that exists about the company, and because the expectations are all over the map," the "Mad Money" host said.
Cramer says that he owns Apple because it's cheaper than the average stock and has fabulous growth statistics, a good balance sheet and a decent dividend. Its earnings-per-share ratio still trades at a discount in comparison to other stocks of the S&P 500.
"In fact, I like Apple not for the watch but for Apple Pay, something I see retailers fighting but in the end having to give in to because so many people use iPhones," Cramer said.
Read More Cramer: How to play Apple and make a fortune
In the Lightning Round, Cramer gave his take on a few caller favorite stocks:
Spirit Airlines: "You know I like Spirit Air. I like Ben Baldanza and I think they are going to do fine. I know people are turning on the airlines, that is a mistake. I say buy, buy, buy."
Chicago Bridge & Iron: "I'm concerned about it because I don't like the energy infrastructure business right now and I think it's going to be too hard for them to be able to beat the numbers."
Read More Lightning Round: A mistake to turn on this sector