Starting with the NCAA southern region, the top two seeds are Duke and Gonzaga University.
In Cramer's opinion Duke is a lot like Disney, with both representing amazing branding with a fabulous head coach.
"I mean, this stock got downgraded today, big splash, and it went up anyways—that's almost home-court advantage," Cramer added.
Duke's head coach, Mike Krzyzewski, just became the very first coach to have 1,000 wins under his belt. Likewise, that record reminds Cramer of Disney CEO Bob Iger, who has tripled his firm's stock value since he took over some 10 years ago.
Then there is the second-seed pick in the southern region, Gonzaga University in Spokane, Washington. Of course, Cramer immediately thought of Boeing, a strong company with top leadership and roots in Washington.
"Gonzaga has become a blue chip name in college basketball, with 15 consecutive NCAA appearances, and in the same way, Boeing is absolutely a must-own stock," Cramer said.
Lately, both Boeing and Gonzaga have been on fire. In 2013 Gonzaga was the No. 1 seed, and this year it's No. 2 for the second time. Boeing has shown the same strength, with its stock doubling since 2012. Cramer thinks Boeing has room to fly even higher with the low price of oil, too.
Read MoreCramer's March Madness: Top southern stock picks