Stocks struggled for consensus in the days ahead of the release of the March jobs report on Good Friday, when stock markets are closed. Only the futures market will be open on Friday after the economic report comes out at 8:30 a.m.
That leaves an entire day before investors can take action on the jobs report on Monday. Since European markets and most Asian exchanges are closed on Monday, U.S. markets will have little overseas movement to trade off.
"Basically any number lower than anticipated will probably be welcomed that doesn't raise Fed fears. On the other hand, a number higher (than anticipated) could induce Fed fears," said Peter Cardillo, chief market economist at Rockwell Global Capital.
Analysts expect an increase of 245,000 in nonfarm payrolls in March, with the unemployment rate unchanged at 5.5 percent. Average hourly wages are expected to increase 0.2 percent.
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A rough Monday doesn't spell doom for the entire week, however.
Stocks actually traded positive 70 percent of the time with a median gain of more than 0.70 percent, Kensho analysis showed.
Disclosure: CNBC's parent NBCUniversal is a minority investor in Kensho.