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CNBC's Jim Cramer said that Salesforce Chairman and CEO Mark Benioff would not comment on a possible takeover.
The report didn't name any particular suitors, though it noted that a takeover of Salesforce would be the largest software acquisition ever, according to Bloomberg data.
Salesforce, IBM and Oracle all refused to comment to CNBC on this report.
Shares were trading at all-time highs Wednesday. The company went public in 2004.