Lopez, a 44-year-old, former mayor, surrendered during a public demonstration shortly after Maduro called for his imprisonment.
"Leopoldo Lopez turned himself in for three reasons," Tintori told CNBC. "The first one, Leopoldo Lopez is innocent. We asked to release Leopoldo Lopez and all the political prisoners in Venezuela. The second, Leopoldo loves Venezuela and is never going to leave the country, and third, Leopoldo wants to unmask Maduro."
Tintori, a former kite-surfing champion and television host, has emerged as a human rights activist, trying to raise awareness about Venezuela's economic and social chaos. She has embarked on an international tour to ask world leaders for support for her husband's freedom. Ex-presidents of Colombia, Peru, Mexico and Spain are among the leaders supporting Tintori's cause.
Lopez is not alone. There are 89 prisoners being held in Venezuela for political reasons, according to a Venezuelan non-governmental organization. Among them are two other mayors from the opposition: Daniel Ceballo and Antonio Ledezma.
Read MoreVenezuelan currency tanks; inflation seen near 100%
"The government feels threatened," said Harold Trinkunas, senior fellow and director of the Latin America Initiative in the Foreign Policy program at Brookings Institution. "The Venezuelan government is increasingly arbitrary in the use of the law to target the opposition. There is an old joke in Latin America: 'For my friends, anything; for my enemies, the law.' (The) Maduro administration practices that."
Lopez's trial is expected to end this month. He is expected to be sentenced to 10 years in jail.
"Sometimes heroes have to be in jail," Tintori said. "We are going to get through this."