The acquisition is about bringing Altera's programmable gate array [PGA] into Intel, "which can really accelerate performance considerably, up to 2x performance improvements as a result of the combination of the products," Krzanich said in an interview with CNBC's "Closing Bell."
Intel announced earlier Monday it agreed to buy Altera for $16.7 billion, or $54 a share. Intel ended the day up 1.61 percent, and Altera closed up 5.79 percent.
Krzanic said Intel's customers were asking for the products.
"They want this power performance that this product can deliver," he said.
"For the big cloud providers, a 2x improvement in performance is huge. It really provides them not only with a competitive advantage but a cost advantage as well. That's what really fuels the cloud."
Because the industry is maturing, there will be M&A occurring for at least the near future, Krzanic noted.
While Intel is always "on the lookout" for acquisitions, he said this latest one will take some time to go through the regulatory process.
"Certainly we're going to be looking for value to our shareholders constantly, both internal investment and investments in acquisitions."
The company also does a lot of acquisitions in the smaller range and will continue to do that, he said.
—Reuters contributed to this report.