Australia's S&P ASX 200 index ended near the previous day's close, after banking heavyweights such as Australia and New Zealand Banking Group, as well as National Australia Bank, trimmed gains.
Within the resources sector, gold producers underperformed as spot gold lingered at one-week lows. Evolution Mining and Newcrest Mining tanked 4.4 and 3.3 percent, respectively.
By contrast, energy counters cheered firmer crude oil prices in Asian trade; Woodside Petroleum and Santos moved up 0.2 and 0.5 percent, respectively.
Shares of recruitment firm Skilled Group rallied 7.1 percent after announcing that it accepted a 422 million Australian dollars ($325 million) takeover deal from rival Programmed Maintenance.
Kospi adds 0.2%
South Korea's key Kospi index eked out marginal gains to extend a five-day winning streak.
The pharmaceutical sector outperformed, with a gauge of healthcare stocks jumping nearly 3 percent. Within the sector, Daewoong Pharmaceutical and Hyundai Pharmaceutical leaped 6 and 9.2 percent, respectively.
Blue chips lost some of Tuesday's strong upward momentum, thereby limiting the bourse's gains. Samsung Electronics eased nearly 2 percent after bolstering 3 percent in the previous session, while Hyundai Motor elevated 1.5 percent.
Meanwhile, the country's health ministry reported four new cases of Middle East Respiratory Syndrome (MERS) on Wednesday, bringing the total number of cases to 179.
— CNBC's Holly Ellyatt contributed to this market report