The Greek debt drama has been hanging over markets for years now, and with each new critical deadline, there has been a heightened sense of anxiety.
But history shows, the U.S. stock market has more or less been able to take the fears about potential default and crisis in stride. (Tweet This)
CNBC used quantitative analysis tool Kensho to look at 16 instances back to 2011 in which there were indications of Greece potentially exiting the European Union.
The Kensho study found that if an investor bought on the rumor the day before the event and sold on the day of the event, U.S. markets were indifferent to the news, trading flat on the day of the event.
European stocks, particularly those in Greece, had a more negative response.
John Burke, CEO of Burke Financial Strategies, said that even as stocks react in the short-term to headlines on Greece, the moves are moderate.
In fact, despite mounting pressure for Greece and its creditors to reach a deal before June 30, the S&P 500 has slowly crept higher with 3 percent gains year to date. During the recent round of headlines, though, the S&P has been basically flat, losing a scant 0.3 percent in the eight weeks ending Friday.
The index was down just slightly after the reported rejection of Athens' proposals on Wednesday.
"Mostly people realize one way or another the rest of the world is going to be OK," Burke said.
—With reporting by CNBC's Gina Francolla.
Disclosure: NBCUniversal, parent of CNBC, is a minority investor in Kensho.