If you are an investor with an urge to make yourself look like a fool in trading after hours, then Cramer says to look no further than what just happened with Chipotle.
Chipotle's stock had been under pressure after weaker than expected guidance last quarter. However, the stock ran up approximately 10 percent going into Tuesday's earnings, mainly because of rumors that the worst might finally be over.
But one minute after it reported on Tuesday, the quarter was immediately labeled a miss. As a result, the stock that closed at $674 on Tuesday plunged more than 50 points. The longs got rid of the stock, and the short sellers placed their bets against the once red-hot sock.
Finally, the game changed when Hartung explained that Chipotle intended to buy back stock with all of the cash it has accumulated on its balance sheet. In fact, it had already put $100 million to work over the past three months.
That was it. By the end of the call, the stock was back in the black.
Cramer's moral of the story?
"Wait, don't trade right after you see the headlines and listen to what the darned CFO has to say," the "Mad Money" host said. (Tweet This)
Read More Cramer: Dangers of trading on earnings after hours
One company with an exciting story is Spark Therapeutics. It uses gene therapy to address major unmet medical needs and has developed one-time treatments that basically cure patients with debilitating genetic diseases.
For example, the most advanced product in Spark's pipeline is a treatment for a rare gene mutation that causes blindness. Early stage data showed that it can actually reverse vision loss in children with this genetic condition, for which there is currently no existing cure.
Cramer found this story so intriguing that he decided to sit down with Spark's co-founder and CEO Jeff D. Marrazzo.
"Part of it is that we are really able to understand the genetic basis of disorders in a much, much better rate. We are also now being able to do the necessary genetic testing to identify patients and understand these very specific diseases," Marrazzo said.
In the Lightning Round, Cramer gave his take on a few caller favorite stocks:
American Tower Corp: "I like American Tower because Sprint and T-Mobile need more tower space and the stock has been acting better, you know that's good. I saw Crown Castle, it was iffy today. I don't care for it. I like American Tower."
Twenty-First Century Fox Inc: "Yes, I think Fox is okay. We owned it for actionalerts.com and then decided to sell it for greener pastures ahead. I'm considering it a don't buy."
Read MoreLightning Round: Greener pastures ahead for this