The Novo Nordisk CEO topped Harvard Business Review's list of the 100 best-performing CEOs this year. Former Cisco Systems CEO John Chambers, who left the position in July, ranked second.
The list evaluates executives not only on financial performance but also environmental and social records.
Sorensen joined the Danish pharmaceutical company in 1982 and became CEO in 2000. Novo Nordisk shares listed on the Copenhagen Stock Exchange have climbed about 40 percent this year.
Here are the top 10 CEOs as ranked by Harvard Business Review:
Embattled former Volkswagen CEO Martin Winterkorn, who stepped down last month amid an emissions cheating scandal, ranked at No. 20 on the list.