"Media, tech, retail and education are our largest and highest growth industries," Piper said.
The partnership with MobileIron is brand new, and the whole purpose is to get into companies with the most sensitive data to protect.
Attendees at the Dropbox event on Wednesday can expect to hear plenty more along those lines, including partnership updates with security vendors. Sessions will focus on the changing security landscape, employee collaboration, product adoption and customer success.
These are all important steps for Dropbox to be a relevant player in enterprise software. But it doesn't mean they'll work.
Read MoreWhat does the stalled Dropbox IPO say about tech?
Like the consumer storage market, the business landscape is littered with competitors. Just look at Box, which is spending 80 percent of its quarterly revenue on sales and marketing to compete with the likes of Microsoft, Google, and Citrix.
Andres Rodriguez, CEO of cloud storage vendor Nasuni, calls Dropbox a "victim of its own success."
The product, which launched in 2008, was such a hit with consumers that it infiltrated work environments way before security departments were ready..
"When it was still early in the adoption cycle, IT was willing to either turn a blind eye or accommodate super users," Rodriguez said. "I've seen a real shift in the past year. Companies are saying this is causing a major concern and have either shut it down or are looking at how to contain it."
Whether Dropbox can provide the solution is the $10 billion question.
Update: MobileIron reported earnings today and said its customer count has now surpassed 10,000.