Several business leaders have dismissed that notion, however and one fund manager told CNBC on Monday that it would largely be a case of "business as usual" if the U.K. left the EU.
"Not much will change in the short-term, there will be some instability post the vote if we choose to leave," Howard Shore, Executive Chairman of Short Capital Group, told CNBC on Monday.
"Not least because if you're being told there will be instability, that's self-reinforcing but fundamentally, terms of trade in the short-term will remain the same while the government negotiates with Europeans and the rest of the world."
"It's not in the Europeans' interests to change anything anymore than it is in our interests. We've got to think of the long-term benefits of leaving," Shore said. "I'm saying that because we're such big net importers of particularly German goods, it's just in much of their interests to keep the terms of trade the same as ours."
Aside from the country's business interests, trade and impact of a potential Brexit could have on the country's financial services industry, a large part of the Brexit debate surrounds immigration and the U.K.'s ability to restrict the number of immigrants and, particularly, benefits for EU migrants.
Shore believed that a vote to leave would allow the U.K. to improve the quality of its foreign workforce rather than cause a "brain drain" of international talent as Remain campaigners fear.
"If we leave the EU we can set our immigration policy based on who we want, not whether you're from Europe, Africa or the Middle East but on whether we want you to come here. Why should we give a particular advantage to someone coming from Eastern Europe over the Middle East or Far East."
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