"I've never had any substantive conversation with Boehner in any respect," the GOP presidential hopeful said at a news conference in Indiana.
"So when he says I'm the worst guy he's ever worked with, he's never worked with me. John Boehner's remarks reveal everything that's wrong and corrupt about Washington, everything you're angry with. When John Boehner calls me Lucifer, he's not directing that at me. He's directing it at you."
Cruz's comments came a day after Boehner shared some choice words about the presidential candidates during an appearance at Stanford University.
When asked about the Texas senator, fellow Republican Boehner said: "Lucifer in the flesh," according to The Stanford Daily. "I have Democrat friends and Republican friends. I get along with almost everyone, but I have never worked with a more miserable son of a bitch in my life."