Part of the film's success can be attributed to a highly successful social media campaign, including asking fans to choose a side with the hashtags #TeamCap and #TeamIronMan.
"This film has developed a great, engaging social media campaign," said Loria. "Positive reviews helped drive word of mouth a couple of weeks ago, and now that overseas have already seen it we'll start seeing more buzz on social media."
"Captain America: Civil War" is the 13th entry in the Marvel movie canon, but De Blieck doesn't expect the studio's fortunes to change.
"The Marvel movie machine has always had its ups and downs," he said. "Not every movie has been perfect, though I'm sure they've all made money. I think it will continue on that way for a while -- with lots of good movies paving the way for the occasional ridiculous blockbuster."
"Captain America: Civil War" opens in U.S. theaters – as well as in China, India, Canada and more – on May 6, where it is expected to make as much as $200 million in its opening weekend. To receive the crown for best opening weekend domestically from the Marvel cinematic universe franchise, it has to top the impressive figure of $207.4 million, from "Marvel's The Avengers" which nonetheless pales against "Star Wars: The Force Awakens" and its opening weekend tally of $248 million.
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-- With contribution from CNBC's Alexandra Gibbs