It is the latest high-profile merger to go down the drain and it has nothing to do with overzealous regulators and everything to do with the nature of the deals changing, Julie Brill said.
"I do think that this is a trend we are seeing — very large mergers attempting to be pushed through and I think the parties need to be careful about this process and know that the regulators are very serious about trying to protect competition in this country," she said in an interview with CNBC's "Power Lunch."
"When costs go up to businesses then those costs can get passed onto consumers."
On Tuesday, a court ruled that Office Depot and Staples may not merge, sending shares of the companies plummeting Wednesday.
The FTC called the ruling great news, noting that the deal "would eliminate head-to-head competition between Staples and Office Depot and likely lead to higher prices and lower quality service for large businesses that buy office supplies."