Advanced Accelerator Applications Announces Expansion of Theranostic Pipeline with NeoBOMB1

SAINT-GENIS-POUILLY, France, June 07, 2016 (GLOBE NEWSWIRE) -- Advanced Accelerator Applications S.A. (NASDAQ:AAAP) (“AAA” or “the Company”), an international specialist in Molecular Nuclear Medicine (MNM), today announced the expansion of its pipeline of theranostic products with the addition of NeoBOMB1, a novel GRPR antagonist, and that two abstracts presenting NeoBOMB1 data have been selected for oral presentations at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2016 Annual Meeting in San Diego, California. One of the two submissions was given the “International Best Abstract” Award.

The details of the presentations are as follows:

Abstract #331: 68Ga/177Lu-NeoBOMB1, a novel radiolabeled GRPR antagonist for theranostic use
Presenter: Simone Dalm, Msc, Department of Radiology & Nuclear Medicine, Erasmus University Medical Center
Session Title: Preclinical probes for Oncology-1 - Room 29 CD
Session Date: Tuesday, June 14, 2016
Session Time: 10:00 a.m. – 10:12 a.m. ET

Abstract #583: [68Ga]NeoBOMB1, a new potent GRPR-antagonist for PET imaging - Preclinical and first clinical evaluation in prostate cancer
Presenter: Theodosia Maina, PhD, Director of Research, National Centre of Scientific Research "Demokritos"
Session Title: Oncology: First-in-Human Imaging Studies - Room 30 B
Session Date: Wednesday, June 15, 2016
Session Time: 8:36 a.m. – 8:48 a.m. ET

These two independent studies evaluated NeoBOMB1 in a prostate cancer model, with both diagnostic and therapeutic isotopes, including an initial clinical evaluation performed in prostate cancer patients.

NeoBOMB1 is a unique new generation antagonist bombesin analogue, which binds selectively and with high affinity to the GRP receptors expressed by several types of tumors, including prostate, breast and gastro-intestinal stromal tumors. GRP receptors are considered relevant molecular targets for both therapeutic and diagnostic purposes in those cancers. In vitro and in vivo pre-clinical models have demonstrated that NeoBOMB1 has desirable imaging properties as well as a favorable pharmacokinetic and safety profile.

We are broadening our pipeline with NeoBOMB1 by leveraging a formula that we have already successfully applied to develop our lead therapeutic candidate, Lutathera and diagnostic product, Somakit, which was recently approved by the US Food and Drug Administration. Our plan is to radiolabel NeoBOMB1 to develop a theranostic pair: 177Lu-NeoBOMB1 for treatment and a 68Ga-NeoBOMB1 for diagnosis. I believe NeoBOMB1 may have potential utility in PET diagnosis and as a targeted therapy in GRPR-expressing malignancies,” said Stefano Buono, Chief Executive Officer of AAA.

NeoBOMB1 was originally developed by Marion De Jong of Erasmus University Medical Center and Theadosia Maina and Berthold Nock of Demokritos. AAA has acquired the rights to develop NeoBOMB1 and is currently planning three clinical studies in different indications including gastrointestinal stromal tumors, prostate cancer and breast cancer.

About Advanced Accelerator Applications

Advanced Accelerator Applications (AAA) is an innovative radiopharmaceutical company that develops, produces and commercializes Molecular Nuclear Medicine (MNM) products. AAA’s lead therapeutic product candidate, Lutathera, is a novel MNM compound that AAA is currently developing for the treatment of Neuro Endocrine Tumors, a significant unmet medical need. Founded in 2002, AAA has its headquarters in Saint-Genis-Pouilly, France. AAA currently has 20 production and R&D facilities able to manufacture both diagnostics and therapeutic MNM products, and has over 440 employees in 13 countries (France, Italy, UK, Germany, Switzerland, Spain, Poland, Portugal, The Netherlands, Belgium, Israel, U.S. and Canada). AAA reported sales of €88.6 million in 2015 (+26.8% vs. 2014) and sales of €26.92 million for 1Q 2016 (+29.6% vs. 1Q15). AAA is listed on the Nasdaq Global Select Market under the ticker “AAAP”. For more information please visit:

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Contacts AAA Media Relations Véronique Mermet Communications Officer Tel: +33 (0)4 50 99 30 70 AAA Investor Relations Jordan Silverstein Director of Investor Relations Tel: + 1-212-235-2394 Media enquiries FTI Consulting Shauna Elkin Tel: +1-212-850-5613 Axess Public Relations (Italy) Dario Francolino Tel: +39 34888180

Source: Advanced Accelerator Applications