U.S. stock index futures indicated a lower open Tuesday, after being closed Monday for the July 4 holiday, with "risk-on" sentiment pausing for breath after a strong rally last week.
Dow futures were briefly off about 100 points, while S&P 500 and Nasdaq futures were down 11 points and 25 points, respectively.
Equities around the world have broken their post-Brexit winning streak as uncertainty surrounding the U.K. vote still persists among investors. The ruling Conservative party will hold the first stage of its selection process for a new leader on Tuesday evening and potential candidates have been busy putting their ideas forward for the post-Brexit environment.
Sterling has also fallen to a 2-1/2 year low against the euro and redemptions in one U.K. property fund have been halted after a string of outflows. The pound also fell to a fresh 31-year-low against the dollar early Tuesday.
European stocks extended losses in mid-morning trade on Tuesday with added volatility in the Italian banking sector.