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"What we might see happen under a Clinton presidency in the first 100 days is a deal," Democratic strategist David Goodfriend said on "Squawk on the Street. " "I do believe that Republicans in the House, under Paul Ryan's leadership, would want to do deals with a President Clinton."
Goodfriend said he thinks Clinton will focus on infrastructure as president, an issue that Republican presidential candidate Donald Trump has also wanted to improve.
Clinton announced a $275 billion infrastructure spending plan in December that would be funded through taxes on the wealthy. Trump said he would want to spend more than twice as much for his plan by using an infrastructure fund supported by government bonds.
"Certainly from a budget standpoint, Moody's Analytics has said the Clinton plan would not add to the deficit or the debt. That is significant," Goodfriend said. "If you're both pro-jobs, pro-working class, pro-infrastructure spending, but you care about deficits, then Hillary Clinton measures up better than Donald Trump."
Goodfriend also noted a fracturing between Republicans and Donald Trump on economic issues.
"There are Republicans that are refusing to endorse Donald Trump, partly because of his outlandish statements, but also because he is not sticking to Republican Party orthodoxy on a lot of these economic messages, " Goodfriend said.
Goodfriend said that a person running for president must appeal to the electorate and that the person will have mandates that members of Congress must listen to if they want to be re-elected.
"You're seeing previews of that in the number of Republicans in the House that are starting to endorse Hillary Clinton, which is very unusual, " Goodfriend said.
He said there are also Republicans in Congress that would never agree to pay for infrastructure spending with taxes under a Clinton presidency.
"Those votes are always going to be out of reach to Hillary Clinton," said Goodfriend. "The real question is whether moderate Republicans and the Democratic majority in the Senate will be enough to get these plans through."