While any deal is unlikely to happen soon, the revelation had some scratching their heads on why Salesforce would be interested in the social platform.
"It is highly unusual to read so much about someone ... Marc Benioff just determined to buy it and see the stock go down very big and have it play out in the media to some degree. That's never been the way to get something cheaper," Cramer said on "Squawk on the Street."
He added, "Marc sees this company in a different light. He just doesn't see it the way it is. ... He's seeing it as a way for Procter & Gamble to stay in touch with its customers."
Cramer also expressed last week that Salesforce could wield Twitter's user data to strategically reach customers.
Separately, Oppenheimer downgraded the social media platform Monday to underperform from perform, based in part it says on slowed user growth and decreased user engagement.
Twitter's stock was trading lower mid-morning Monday at $22.12 a share. The stock is down more than 4 percent this year to date.
— CNBC's Anita Balakrishnan contributed to this report.