They weren't the only ones criticizing Trump on Friday as the story started to look like a tipping point for his detractors within the GOP.
Sen. Mark Kirk (R-IL), who is in a tough race and has refused to endorse Trump tweeted that Trump "should drop out" and that the GOP should move to organize an emergency replacement. He called Trump "a malignant clown — unprepared and unfit to be president of the United States."
Sen. Kelly Ayotte (R-NH), who is under fire in her home state for calling Trump a role model in a recent debate, immediately issued a statement on Friday calling Trump's comments "totally inappropriate and offensive."
Sen. Richard Burr (R-NC), who supports Trump and also faces a difficult re-election, called Trump's comments "inappropriate and completely unacceptable"on Twitter. Senator Pat Toomey (R-PA) tweeted that they were "outrageous and unacceptable."
"I think the wheels just came off," a top staffer at a GOP super PAC said.
In addition to politicians in swing states, the Trump audio prompted indignant statements from former rivals like John Kasich and Jeb Bush.
"Hitting on married women? Condoning assault? Such vile degradations demean our wives and daughters and corrupt America's face to the world," 2012 GOP nominee Mitt Romney, who has denounced Trump throughout his candidacy, tweeted.
Jon Huntsman, the former governor of Utah who recently indicated he would support Trump, withdrew his endorsement on Friday and called on Trump to leave the race.
At the same time, Trump did get some backup from prominent evangelical supporters who indicated a willingness to overlook his sins.
"I in no way condone [the comments] but I don't condemn him," Pastor Darrell Scott, a Trump adviser, said. He explained that Trump's 2005 remarks came before he had "spiritual influences" in his life.
Democrats, eager to fan the flames, are rapidly moving to demand more Republican candidates renounce Trump or be tarred by association. Hillary Clinton's campaign rapidly
featuring the 2005 footage.
The news comes as Trump looks to bounce back in Sunday's town hall with Clinton after a difficult first debate last month that included withering attacks on his treatment of women — attacks Trump made dramatically worse the next week by feuding with former Miss Universe Alicia Machado and telling voters to "check out [a] sex tape" that apparently did not exist.
The sustained fight over Trump's treatment of women helped generate additional stories about his comments and behavior over the years, stories that will only get more attention now.
The Associated Press published a detailed exposé of his work on The Apprentice, with numerous sources recalling lewd and inappropriate remarks similar to the 2005 audio. The Los Angeles Times detailed complaints from Trump employees in a lawsuit that they had to hide staff he found physically unattractive to prevent him from firing them.