"What's happened is, a lot of the bidders are looking at people with lots of followers and seeing the hatred," Cramer said on "Squawk on the Street."
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He continued, "Twitter says listen, we have a filter. I mean the filter filters out a very small amount of the haters, and I know that the haters reduce the value of the company."
Last week, a Financial Times report said that Benioff had ruled out a bid for Twitter, after weeks of speculation that the company could indeed acquire the company.
Salesforce confirmed Benioff's comments to CNBC and declined to comment further. Twitter shares fell as much as 8 percent following the report.
Cramer said Benioff spoke with his shareholder base, and they had told them about the dislike by some for the platform.
Twitter has taken some action in order to deal with abuse, including filtering out mean mentions that users might receive and blocking some tweets based on account origin and behavior.
Twitter stock was trading lower in midmorning trade Monday. The stock is down more than 28 percent year to date.
— CNBC's Anita Balakrishnan contributed to this report.