The letter, released Tuesday and reported on by the Wall Street Journal, lists 13 economic arguments against Trump, but does not specify which (if any) candidate voters choice in lieu of the Republican nominee.
"Donald Trump is a dangerous, destructive choice for the country. He misinforms the electorate, degrades trust in public institutions with conspiracy theories, and promotes willful delusion over engagement with reality," the economists write, according to a copy posted online by the Journal.
"If elected, he poses a unique danger to the functioning of democratic and economic institutions, and to the prosperity of the country. For these reasons, we strongly recommend that you do not vote for Donald Trump," the letter concludes.
Despite the apparent breadth of this week's letter, many economists are also against Democratic nominee Hillary Clinton's policies. In a September letter, 306 economists published a letter against Clinton's "ill-advised economic agenda."