"La La Land", a romantic musical about a struggling actress and a jazz pianist trying to make it in Hollywood, took home Globes for best comedy/musical and for its stars Ryan Gosling and Emma Stone, as well as for director Damien Chazelle, screenplay, score and original song.
"This is a film for dreamers and I think that hope and creativity are the most important things in the world," said Stone.
Independent coming-of-age film "Moonlight" was named best drama movie, while Casey Affleck, star of "Manchester by the Sea" won best drama actor for his role as a man riven by grief.
The Globe wins, handed out by the Hollywood Foreign Press Association, strengthened the front-runner status of "La La Land" and "Moonlight" for the Oscars in February.
Isabelle Huppert was named best drama actress for the French psychological thriller movie "Elle" in an upset win over Natalie Portman for "Jackie."