"You're not going to get advertisers to say, you know what, I got to put my ads where the president tweets. I think you're going to say I got to put my ads where I'm getting the biggest bang for my buck..." Cramer said "Squawk on the Street."
On Thursday, before the bell, Twitter reported fourth-quarter revenue that missed Wall Street's expectations and issued guidance that fell far short of estimates.
Twitter said total advertising revenue was $638 million, down slightly from a year earlier.
Chief Financial Officer Anthony Noto said the company is hearing positive feedback from ad partners, however, "revenue growth will continue to lag audience growth due to the sales cycle, and could be further impacted by the escalating competition for digital advertising spending and our efforts to re-evaluate our revenue product feature portfolio."
Cramer's comments also came after BTIG upgraded Twitter on Wednesday to "buy" from "neutral" with a price target of $25 due to rising usage trends from the political conversation around President Donald Trump's tweets.
"The incessant news flow from the Trump administration playing out on Twitter and the ensuing global reaction pushes Twitter users to be increasingly engaged with the platform," analyst Richard Greenfield wrote in a note to clients.