(Adds details about Senate vote, Collins, Flake and McCain)
WASHINGTON, Dec 17 (Reuters) - Top U.S. Republicans said on Sunday they expected Congress to pass a tax code overhaul this week, with a Senate vote as early as Tuesday and President Donald Trump aiming to sign the bill by week's end.
John Cornyn, the No. 2 U.S. Senate Republican, said in an interview on ABC's "This Week" that he was "confident" the Senate would pass the legislation, "probably on Tuesday."
Republican Representative Kevin Brady said he believed his party had the votes to pass the bill.
"I think we are headed - the American people are headed - for a big win on Tuesday," Brady, the House of Representatives' top tax writer, said on Fox News' "Sunday Morning Futures with Maria Bartiromo."
"We've worked hard to make sure that those strange Senate rules don't hang this up in any way," Brady added. "I am confident that's the case."
If passed, the bill would be the biggest U.S. tax rewrite since 1986 and provide Republican lawmakers and Trump with their first major legislative victory since they took control of the White House in January in addition to Congress.
Republicans have a slim 52-48 Senate majority and cannot lose more than two votes and still pass tax legislation. Democrats are unified against the measure, calling it a giveaway to corporations and the rich that would drive up the federal deficit.
Last week, on-the-fence Republican Senators Marco Rubio and Bob Corker said they would support the tax overhaul. Senators Susan Collins and Mike Lee put out positive statements but did not explicitly say they would vote for it. Collins' office said on Sunday that "she's still reviewing the bill."
Republican Senator Jeff Flake cast a vote for an earlier Senate version despite deficit concerns, but he is undecided on the final legislation, his office said on Sunday.
Senators Thad Cochran and John McCain have been ill in recent weeks and have missed votes. Cochran's office said last week he was expected to vote on the tax bill. McCain, who is battling an aggressive brain tumor, left Washington on Sunday to return to his home state of Arizona, CBS News reported.
The tax bill is expected to add at least $1 trillion to the $20 trillion U.S. national debt over 10 years, even after accounting for the economic growth it might spur, according to independent government analyses.
The bill would cut the corporate income tax rate to 21 percent from 35 percent and create a 20 percent income tax deduction for owners of "pass-through" businesses, such as partnerships and sole proprietorships.
It would offer a mixed bag for individuals, including middle-class workers, by roughly doubling a standard deduction that does not require itemization, but eliminating or scaling back other popular itemized deductions and exemptions.
The bill would maintain seven individual and family income tax brackets but cut rates. Highest-earning Americans would pay 37 percent, down from 39.6 percent.
Most individual provisions, including the lower tax rates, are temporary and would expire, while the corporate rate cut and other business provisions would be permanent.
Stock markets have been rallying for months in anticipation of sharply lower tax rates for corporations, with Wall Street's three major equities indexes closing at record highs on Friday.
Treasury Secretary Steven Mnuchin told CBS News' "Face the Nation" on Sunday that Trump expected to realize his goal of signing the tax bill before Christmas.
"This is a historic event," Mnuchin said. "People said we wouldn't get this done; we're on the verge of getting this done." (Additional reporting by Sarah N. Lynch; Editing by Lisa Von Ahn and Peter Cooney)