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UPDATE 5-Brent hits highest since 2014 after Trump missile warning

* Airlines warned of possible air strikes

* Brent hits highest since December 2014

* Rising U.S. output and inventories weigh (Updates prices)

LONDON, April 11 (Reuters) - Oil hit its highest in more than three years on Wednesday after U.S. President Donald Trump threatened to fire missiles at Syria in response to a suspected chemical attack last week.

Some major airlines were re-routing flights on Wednesday after Europe's air traffic control agency warned aircraft flying in the eastern Mediterranean to exercise caution due to possible air strikes on Syria.

Trump has criticised Moscow for standing by Syrian President Bashar al-Assad.

"Russia vows to shoot down any and all missiles fired at Syria. Get ready Russia, because they will be coming, nice and new and 'smart!'," he wrote in a post on Twitter on Wednesday.

Brent crude jumped to a high of nearly $72 a barrel, its strongest since early December 2014, after Trump's comments, while gold rallied for a fourth day as investors ditched risk-linked assets such as equities.

Brent rose 60 cents on the day to $71.64 a barrel by 1341 GMT, while U.S. crude futures rose 58 cents to $66.09, down from a session peak of $66.44.

The United States and its allies are considering air strikes against Assad's forces following a suspected poison gas attack last weekend.

Syria is not a significant oil producer, but any sign of conflict in the region tends to trigger concern about potential disruption to crude flows across the wider Middle East, home to some of the world's biggest producers.

There are also concerns that the United States could renew sanctions against Iran.

"The focus right now is definitely on a possible military strike against Syria," said Commerzbank's head of commodity research, Eugen Weinberg.

"We think the fundamentals do not justify the current price, but unfortunately the market is focusing more on the politics and ignoring some of the warning signs, especially the hike in U.S. oil production."

Saudi Arabia Energy Minister Khalid al-Falih said on Wednesday that his country would not sit by and let another supply glut surface, implying that the de-facto leader of the Organization of the Petroleum Exporting Countries (OPEC) would continue to withhold supply.

Not all oil market indicators suggest the price will continue to rally strongly, analysts said.

U.S. crude inventories rose by 1.8 million barrels to 429.1 million barrels in the week to April 6, according to a report by the American Petroleum Institute (API) on Tuesday, compared with analysts' expectations for a decrease of 189,000 barrels.

The U.S. Energy Information Administration (EIA) said on Tuesday that it expects domestic crude oil production in 2019 to rise by more than previously expected, driven largely by growing U.S. shale output. (Additional reporting by Henning Gloystein in Singapore Editing by Jane Merriman and David Goodman)