The eight teams make one pick per round, for three rounds. Competitors can choose from a list of 60 investments, ranging from big Dow Jones Industrial companies like and , to tech giants like Facebook and Amazon. Bitcoin, , and are also on the list.
The winner will be chosen based on their pick's performance, not including dividends, from the stock's closing price on Apr. 26, 2018, through the Super Bowl on Feb. 3, 2019.
Here is the draft order, chosen randomly earlier this week:
While the first two rounds will be televised, the final round will be available via live-stream at 3 p.m. ET on CNBC.com, Facebook, Amazon Fire TV and Apple TV.
Here is a live round-up of Thursday's picks:
Stevens Institute Investment Club led the first round pick, and went with Facebook, citing key revenue drivers like artificial intelligence.
"After the privacy scandals the stock took a hit but they're on the rebound after great earnings," said a member of the Stevens team.
The stock is up 10 percent Thursday.
Todd Gordon's team made the second pick of the day, picking cryptocurrency bitcoin as the squad's first investment.
"I can't believe I was given this gift," Gordon said after making the pick. "This is a new digital currency revolution, we've seen this be embraced by institutions, Goldman now has a trading desk."
Though Gordon acknowledged that the price of bitcoin has fallen roughly 50 percent since its highest last year, he argued that "stability has been found."
The price of bitcoin was hovering around $8,850 Thursday afternoon, according to Coinbase.
Defending champion Kevin O'Leary went with oil giant Chevron.
"I'm feeling bullish about energy, it'll be reflected in the stock, and soon I'll be polishing my other trophy," O'Leary said, holding his trophy from last year.
Shares of Chevron were up 0.75 percent Thursday.
The Beardstown Ladies went with Celgene as their first-round pick, hoping to tap into what they consider a cheap value play.
"If we're nearly the year now, we've got the potential to grow," said Buffy Tillitt-Pratt. "This is a value play ... I know it's a drug company, but they're working on drugs for autoimmune diseases, and that's a big issue right now."
Shares of Celgene were up 3.3 percent Thursday, but are down more than 26 percent over the last 12 months.
Former NFL running back Eric Dickerson, who was in the CNBC draft for the first time, also went with the energy sector.
"As a former athlete, you want to have a good team around you, and I think this is the way to go," Dickerson said. His first pick would have been bitcoin, he said.
Shares of the Exxon Mobil were up roughly 1 percent Thursday but have dropped about 4 percent this year.
Tim Seymour of Seymour Asset Management, a returning CNBC Stock Draft player, elected to go with Amgen as his first-round pick, saying he likes the biotech space for reasons highlighted by The Beardstown Ladies.
"Amgen, to me, trades cheap to the peer group," Seymour said in an interview. "I think there's an M&A possibility out there ... I think Amgen and Celgene are both going to toe-to-toe."
Shares of Amgen were up 0.7 percent Thursday.
Former NFL kicker Nick Lowery went with tech giant Amazon, thanks to earnings, and its ability to "cannibalize the market."
"There's been a bit of a buyback but they are a Sean McVay disruptor. Amazon is rewriting the rules in the same way Sean McVay in one year took the Rams and turned them around," Lowery said.
Shares of Amazon were up 4 percent Thursday, and have risen more than 30 percent this year. The company reports its first-quarter earnings after the markets close Thursday.
Rounding out the first round, Bethenny Frankel chose beaten down General Electric as her first choice, betting that the bruised industrial conglomerate can stage a comeback in the next year.
"I'm disruptive, I bet on the underdog," Frankel explained. "I think that the parts are worth more than the sum. They're in a turn-around phrase, they're restructuring, this is my pick and I stand by it."
Though shares of GE were up 2.5 percent Thursday, the stock has swooned over the past 12 months, down more than 50 percent.
To kick off the second round, Stevens Institute Investment Club went with Disney, highlighting its proposed acquisition for 21st Century Fox, and move into streaming.
"We think they'll start snatching customers from Netflix," the Stevens team said. "We think they're undervalued."
Shares of Disney were down 1 percent Thursday and have fallen roughly 13 percent this year.
Following up on his first-round choice of bitcoin, Gordon decided to go with chipmaker Nvidia in the second round.
"Talk about just an amazing technology company," Gordon said. "We have a leader, a chip leader. We've got autonomous cars, a mining space," adding that he the first two rounds couldn't have gone any better for his team.
Shares of Nvidia were up 3.7 percent Thursday and up 116 percent over the past 12 months.
"I assume an acquisition in the next 12 months at a much higher premium," O'Leary said. "If Albertsons is buying Plated, who's going to buy Blue Apron?" O'Leary said.
Blue Apron shares are down 80 percent since its IPO in June but the stock surged 10 percent Thursday after O'Leary's bullish call.
The Beardstown Ladies made Apple their second pick, deciding on the iPhone maker despite growing concerns about the success of the company's latest phone models.
"We've studied the fundamentals, it's a strong company," argued Buffy Tillitt-Pratt. "They've got $200 billion in the bank, if they want to buy some other companies up, they've got plenty of money. They're PE is only 18, which is low for a tech stock."
Shares of Apple were modestly higher Thursday, up 0.3 percent in afternoon trading despite weakness over the past month.
Eric Dickerson went with another energy company for the second round with Anadarko Petroleum. The former NFL running back expects slow, steady growth from the company.
"Being a running back, I'm gonna run it slow and easy. 10 to 15 percent wins this whole deal," he said. "Since they got bitcoin, I went to my second pick."
Shares of the company rose about 1 percent Thursday. Year to date, shares are up more than 25 percent.
Tim Seymour's second pick was DropBox, the cloud storage company that recently celebrated its initial public offering in March.
"Bottom-line we're looking for high-delta stocks here," Seymour said. "Through the catalyst, through the IPO, I think you've worked through some of the lock-up."
Shares of Dropbox rose more than 2 percent Thursday after Seymour made his choice, though the stock is down 3.1 percent over the past month.
Nick Lowery went with Wall Street giant Goldman Sachs in the second round. The former NFL kicker cited volatility and rising interest rates as bullish reasons to bet on the bank.
"It's like Nick Foles, he's tough he's gonna get it done," Lowery said, referring to the Philadelphia Eagles Super Bowl- winning quarterback. "It's the right thing looking at the market in the next six months."
Shares of the bank were up 0.7 percent Thursday but have dropped about 5 percent so far this year.
Bethenny Frankel closed out the second round with her selection of music streaming company Spotify, which celebrated its IPO earlier this month.
"It's the yin to my yang," Frankel explained. "GE was more of a conservative, growth play and this is more of a future play: streaming music is the future."
"I'm all about Spotify," she added.
Shares of Spotify rose on Thursday, up 2.5 percent in mid-afternoon trading.
For their third and final pick, Stevens Institute Investment Club chose pharmaceutical company SAGE Therapeutics.
"We've pinpointed them as a possible takeover target in the pharmaceutical market," a Stevens trader said. "We went relatively safe in the first couple of rounds, this is the home run ball."
Shares of the company rose 3 percent Thursday but have dropped roughly 12 percent this year.
For their third and final round, Todd's Gordon's crew picked Netflix, the online video content streaming provider and member of the so-called "FANG" stocks.
"They're going to put $1.5 billion of debt out there to continue to drive that original content," Gordon said. "The chart looks awesome."
Easily the best performing "FANG" stock over the past 12 months, Netflix shares are up 109 percent since April 2017 and were up 2.7 percent Thursday.
For the last round, reigning champion Kevin O'Leary went with Boeing, which was among his picks last year.
"I'm going back to who I brought to the prom last year," O'Leary said. "It'll probably be my stabilizer in this contest, then I'll crush it with the other two."
Shares of Boeing have surged 88 percent in the past year, and are up 16 percent in 2018 alone. The stock was trading near $342 Thursday.
The final pick for The Beardstown Ladies was payments services company Visa.
"They're making money on both ends," said Buffy Tillitt-Pratt. "When the guy at the store sells you something, and you use your Visa card, he's paying into Visa for that privilege. When you don't pay your bill on time, you're paying into Visa for that privilege."
Shares of Visa were up 5 percent Thursday, jumping higher after the company beat on both the top and bottom lines and raised guidance.
Eric Dickerson went all-in on energy in the third round, and chose oil. The former NFL player went with Exxon and Anadarko in the first and second rounds.
"I'm Texas born, Texas bred, gotta go with oil," Dickerson said. "I'm going all in."
U.S. West Texas Intermediate (WTI) crude futures ended Thursday's session up 14 cents at $68.19 per barrel, while Brent crude oil futures were last up 74 cents, or 1 percent, at $74.74 a barrel by 2:29 p.m. ET.
Tim Seymour's final pick was Chesapeake Energy, the Oklahoma City-based exploration and production company with projects based in several U.S. states.
"I can't get away from my roots, which is to pick companies that are broken down and balance sheets that, I think, are in the repair mode," Seymour explained. "They actually are spending less on cap ex, they're free cash flow positive in the fourth quarter, and they're going to be spinning-off assets. All it will take is some small recovery in their balance sheet for this thing to double."
Shares were up 1.3 percent Thursday, though down more than 44 percent over the past 12 months.
Nick Lowery went with semiconductor company Advanced Micro Devices, or AMD, in the final round. The former NFL kicker called the Santa Clara-based company the "Rob Gronkowski" of the space, and was especially bullish on artificial intelligence.
"It's a disruptor that's going to blow up," Lowery said. "It's the time and the era."
AMD's rose roughly 13 percent Thursday, trading near $11. Shares have risen about 7 percent year to date.
Rounding out the 2018 Stock Draft, Bethenny Frankel chose Google-parent Alphabet.
"Artificial intelligence is the future," said Frankel in explaining her third choice, following her earlier picks of General Electric and Spotify.
Shares of Alphabet were up nearly 2 percent by the closing bell Thursday, and up roughly 17 over the past 12 months.