If his forecast becomes reality, it would be the first $100 million opener for the holiday weekend since "X-Men: Days of Future Past" was released in 2014, he added.
"Memorial weekend needs to get its groove back because it's a very important weekend," he said. "This is where the month of May passes the baton to June and keeps that momentum going."
Last year, the holiday weekend only brought in $181 million for the entire weekend, compared with other years where it saw sales of more than $300 million, Dergarabedian said. The lackluster response continued through the season, with the summer being the lowest grossing one since 2006.
"The summer season is vitally important and Memorial weekend is a big barometer of how the overall summer will perform," he said.
However, Dergarabedian is much more bullish about this summer, which is already off to a good start with Disney's "Avengers: Infinity War" and Fox's "Deadpool 2."
"If this Memorial weekend is any indicator, we're going to have a really strong summer and there's a lot of big movies on the way," he said.
Those films include new installments in the "Jurassic World" and "Mission: Impossible" franchises. Pixar's "Incredibles 2," Marvel's "Ant-Man And The Wasp," Warner Bros.' "Ocean's 8" and Sony Pictures' "Hotel Transylvania 3" are also set to be released this summer.