This incredible success might not have happened without one pivotal conversation that host Adriene Mishler had years ago.
But before the channel really took off, Mishler was at a crossroads in her career.
"I was trying to decide whether or not I should move to LA" from Texas, Mishler told CNBC Make It. "This was after I'd been in a big movie with a big, huge American actor."
With a background in professional theater, Mishler has done voice work for video games and has acted in TV shows such as Rooster Teeth's "Day 5" and in movies like "Joe" and "Good Night."
Mishler recalls agonizing about whether to relocate over coffee with a close friend and mentor. "I was like, 'Should I move? Should I stay? What should I do with my life?'"
The now-YouTube star said her friend gave her some of the "best advice" she's ever received.
"She said, 'The best advice I can give you is, obviously, listen to your guts. But for an actor, and I think this goes for all artists: try to find one thing — and that's not to take away from this passion you have of your art — but try to find one voice outside of that, while you're building this.'"