(Updates with guilty plea, agrees to become government witness)
BOSTON, Jan 9 (Reuters) - The former chief executive of Insys Therapeutics Inc pleaded guilty on Wednesday to engaging in a scheme to bribe doctors to prescribe an addictive opioid medication and has agreed to become a government witness.
Michael Babich, who resigned as the Arizona-based drugmaker's CEO in 2015, pleaded guilty in Boston federal court to conspiracy and mail fraud charges after entering into a cooperation deal with prosecutors.
His plea comes weeks before five former Insys executives and managers including John Kapoor, the companys founder and former chairman, are scheduled to face trial over what prosecutors said was their roles in the wide-ranging scheme.
Babich, 42, faces up to 25 years in prison. But the Arizona resident could receive a more lenient sentence by testifying at Kapoor's Jan. 28 trial.
Kapoor and his co-defendants have pleaded not guilty to racketeering conspiracy. Kapoor's lawyer did not respond to a request for comment.
The case centers on Subsys, Insys' under-the-tongue spray for managing severe pain in cancer patients. It contains fentanyl, an opioid 100 times stronger than morphine.
Prosecutors allege that from 2012 to 2015, Kapoor, Babich and others conspired to bribe doctors in exchange for prescribing Subsys. Prosecutors said they also defrauded insurers into paying for the pain treatment.
Prosecutors allege Insys paid doctors kickbacks in the form of fees to participate in speaker programs ostensibly meant to educate medical professionals about Subsys that were actually sham events.
Insys in August said it had agreed to settle a related U.S. Justice Department probe for at least $150 million. The company has said it is now under new management, which has taken steps to ensure it operates legally going forward.
The case is a major example of their efforts to combat the nation's opioid addiction epidemic, prosecutors said. According to the U.S. Centers for Disease Control and Prevention, opioids were involved in a record 47,600 overdose deaths in 2017.
Babich's plea comes after Alec Burlakoff, Insys' former vice president of sales, pleaded guilty in November and agreed to testify as a government witness.
Babich is married to a former Insys sales representative Natalie Babich, who in 2017 pleaded guilty to conspiring to pay kickbacks.
She testified last month at the trial of Christopher Clough, a former physician assistant in New Hampshire accused of accepting kickbacks from Insys. A federal jury in Concord, New Hampshire convicted Clough on Dec. 18. (Reporting by Nate Raymond in Boston, Editing by Alexia Garamfalvi and Bill Berkrot)