Benioff added that though the Valley is the home of "an incredible technology industry" that "every city in the world craves," some executives in the sector are ignoring issues such as gentrification and homelessness.
"In some ways, San Francisco is the canary in the coal mine," Benioff said in an interview with CNBC's Sara Eisen at the World Economic Forum in Davos, Switzerland. "We have to look at San Francisco and say here's the best technology example in the world and yet the worst homelessness."
"San Francisco is kind of a train wreck, we have a real inequality problem," he said. "It's because of the tech sector."
A one-night count of San Francisco's homeless population in 2017 showed that roughly 7,500 people were without homes, according to figures released by the city in June.