Europe's autos stocks led the losses, down almost 2.3 percent, amid media reports of U.S. concerns that China is pushing back against American demands in trade talks.
U.S. Trade Representative Robert Lighthizer and Treasury Secretary Steven Mnuchin both plan to travel to Beijing next week for another round of negotiations with Chinese Vice Premier Liu He, the Wall Street Journal reported on Tuesday, citing unnamed Trump administration officials.
The world's two largest economies have imposed tariffs on billions of dollars' worth of one another's goods over the past year, battering financial markets and souring business and consumer sentiment.
Looking at individual stocks, Germany's Bayer tumbled to the bottom of the European benchmark after a second U.S. jury found the company's Roundup weed killer was a "substantial factor" in causing a man's cancer. Shares of the pharmaceutical group fell more than 9 percent on the news.
Sticking with Germany, shares of BMW slipped almost 5 percent. It comes after the Munich-based car maker announced it expects pretax profit to fall by over 10 percent in 2019. BMW also launched a sweeping 12 billion euro ($13.6 billion) cost savings and efficiency plan to help offset higher tech investment and currency costs.
Inmarsat surged to the top of the index after the satellite operator announced it had opened talks about a $3.3 billion cash takeover approach from a private equity-led consortium. Shares of the London-listed stock rose more than 13 percent.
Official data published Wednesday showed Britain's main inflation rate ticked up in February, but stayed close to January's two-year low. Consumer prices rose at 1.9 percent in February, after a 1.8 percent increase in January.
Meanwhile, London house prices fell by an annual rate of 1.6 percent in January, amid heightened Brexit uncertainty.