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"The initial tests completed successfully but the final test resulted in an anomaly on the test stand," the company said in a statement.
The issue was earlier reported by Florida Today, which said orange smoke was seen rising above SpaceX's facilities, and that the anomaly was contained with no injuries.
SpaceX said its teams are investigating and are working closely with U.S. National Aeronautics and Space Administration (NASA) partners.
"NASA has been notified about the results of the SpaceX Static Fire Test and the anomaly that occurred during the final test," its administrator Jim Bridenstine said in a tweet.
"This is why we test. We will learn, make the necessary adjustments and safely move forward with our Commercial Crew Program," he added.
NASA has awarded SpaceX and Boeing a total of $6.8 billion to build competing rocket and capsule systems to launch astronauts into orbit from American soil.
In March, the privately owned SpaceX successfully completed its mission of sending an unmanned capsule to the International Space Station and returned safely to Earth, a mission seen as crucial to NASA's plans to resume human space flight from U.S. soil.
SpaceX's first crewed test flight is slated to launch in July with U.S. astronauts Doug Hurley and Bob Behnken.