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* Futures: Dow off 0.39%, S&P up 0.01%, Nasdaq rises 0.22%
April 25 (Reuters) - Dow and S&P futures were pressured by a steep fall in industrial company 3M's shares on Thursday, while upbeat results from high-flying companies Facebook and Microsoft supported Nasdaq futures.
Investors are assessing earnings reports from some of the biggest U.S. companies this week to see if the strong run-up in market since the start of the year is justified as the main Wall Street indexes hover below all-time highs.
The S&P 500 is trading roughly 0.5% below its intraday record hit in late September, while the Nasdaq hit an intra-day record high on Wednesday but failed to close at those levels.
"As the earnings season gains potency, the missing link to a stronger upward move is low volume, suggesting a cautious attitude by investors," said Peter Cardillo, chief market economist at Spartan Capital Securities in New York.
3M Co's shares tumbled 9.1% in premarket trading after the company said it would lay off 2,000 workers globally as it reported a lower-than-expected quarterly profit and cut its 2019 earnings forecast.
Microsoft Corp gained 5% after the company beat Wall Street estimates for quarterly results and predicted continued growth for its cloud computing business.
After a 23% rally in its shares this year, the software company is set to topple Apple Inc as the most valuable publicly listed U.S. company.
Facebook Inc jumped 8.4% after the social media giant's quarterly profit blew past Wall Street's profit estimates and the company set aside $3 billion to cover a settlement with U.S. regulators.
At 7:18 a.m. ET, Dow e-minis were down 104 points, or 0.39%. S&P 500 e-minis were up 0.25 points, or 0.01% and Nasdaq 100 e-minis were up 17.5 points, or 0.22%.
Among other movers, Lam Research gained 4.8% after the semiconductor equipment maker reported better-than-expected quarterly results.
Amazon.com Inc, Intel Corp and Ford Motor Co are among the big names set to report results after the bell.
Economic data due at 8:30 a.m. ET is expected to show new orders for U.S. core capital goods rebounded in March, after falling unexpectedly in February.
Separately, a Labor Department report is expected to show the number of Americans filing applications for unemployment benefits rising 8,000 to a seasonally adjusted 200,000 for the week ended April 20. (Reporting by Sruthi Shankar and Amy Caren Daniel in Bengaluru Editing by Saumyadeb Chakrabarty)