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UPDATE 1-Republican support for Trump's Fed pick Moore erodes

(Recasts headline, lede; adds comment from Ernst)

WASHINGTON, April 30 (Reuters) - Stephen Moore, U.S. President Donald's Trump pick to fill a vacant seat at the Federal Reserve, on Tuesday saw support from fellow Republicans erode, with one senator saying she was "very unlikely" to back him and another calling his nomination "very problematic."

The remarks, from U.S. Republican Senator Joni Ernst and Lindsey Graham, respectively, signaled growing resistance to Trump's bid to put a loyalist on the Fed's policy-setting panel after remarks denigrating women, made over nearly two decades of writing and commentating, were widely reported last week.

Moore did not immediately reply to a voicemail and email from Reuters requesting comment. He has said he is embarrassed at some of his past remarks about women, and said that some were attempts at humor.

Trump announced he would pick Moore for the post just over a month ago, but has not formally nominated him.

It will be a very problematic nomination, Graham said. Asked if he would oppose Moore if nominated, Graham said he would study the pick.

"Very unlikely that I would support that person," Ernst told CNN, adding that she told the White House about her position.

Republicans hold a 53-to-47 majority in the Senate, and given that Democrats are expected to oppose Moore's nomination, he can only lose the support of three Republican senators. (Reporting by Richard Cowan and Susan Heavey, writing by Ann Saphir; editing by Chizu Nomiyama and Jonathan Oatis)