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(Updates throughout, changes byline, dateline)
* Pan-European share index down more than 1%
* E-Minis for S&P500 fall 0.6%
* U.S. Treasury yields at the lowest since September 2017
* German Bund yields at 2 1/2-year low;
LONDON, May 29 (Reuters) - With no sign Sino-U.S. trade tensions will let up and fears of an Italy-European Union confrontation growing again, the global bond rally accelerated on Wednesday, as investors dumped shares and scurried for the safety of German and U.S. government debt.
German yields fell deeper into negative territory and inched towards record lows around minus 0.2%. Ten-year U.S. Treasury bond yields reached 20-month lows, having fallen almost 30 basis points this month.
Wall Street was set to open lower, with S&P500 futures down half a percent after a weak close on Tuesday, following U.S. President Donald Trump's comment that he was "not yet ready" to make a deal with China over trade.
Chinese newspapers responded on Wednesday with a warning Beijing could use rare earths to strike back at the United States.
The prospect of a prolonged standoff between the world's two biggest economies and the likelihood of Europe and Japan getting dragged in are making investors seriously worried about global growth.
Recent economic data, such as purchasing-manager surveys, have disappointed -- U.S. manufacturing growth dropped to 10-year lows.
Another round of tariffs would sharply raise U.S. recession risk, said Justin Onuekwusi, a fund manager at Legal & General Investment Management.
"The market is simply calculating what the impact will be of the next set of tariffs as it doesn't look like the rhetoric is calming down," Onuekwusi said.
"Then we have a weaker growth outlook ... so we have the negative shock of trade added to lower growth and the cushion of protection isn't as good as it was eight to nine months ago."
Those concerns pushed MSCI's global equity index 0.4% lower to a 2 1/2-month low following losses across Asia
European shares opened lower, with Germany's exporter-heavy index down 1% and a pan-European share benchmark losing 1.3%.
On the political front, the news was gloomy, too. Eurosceptic parties gained in recent EU elections, Austria and Greece face elections and Italy's dispute with the European Commission over its budget may be escalating .
In Britain, many reckon risks of a hard Brexit -- crashing out of the EU without a trade agreement in place -- have risen, because candidates lining up to succeed Prime Minister Theresa May are mostly eurosceptic.
All those concerns drove U.S. 10-year yields about 10 basis points below the 3-month rates, an inversion typically seen as a leading indicator of a recession. The inversion is the deepest in almost 12 years.
"What I see as more consistent is that typically when the yield curve inverts you get central bank easings. So the question about recession would be: would the U.S. Fed ease enough to avoid a recession?" said Chris Rands, Sydney-based fixed income portfolio manager at Nikko Asset Management.
U.S. rates futures are pricing in two cuts by the Federal Reserve by the middle of next year to help prop up the country's economy.
Data this week showed a gauge of U.S. manufacturing activity unexpectedly fell in May from the previous month.
That follows earlier disappointing readings on U.S. manufacturing and industrial output, Rands added.
"The fact that you have got a bit more noise around the trade war now at the same time as manufacturing is rolling over -- it's getting people to think that things are a little bit worse than they had expected," he said.
The gap between two and 10-year German Bund yields was the narrowest in 2 1/2 years. Ten-year Bunds now yield minus 0.17% and are down 10 bps since the start of May .
Some of the flows into Bunds are being spurred by an escalation between Italy's ruling coalition and the EU, which is said to be considering punishing Rome for excessive spending.
Italian Deputy Prime Minister Matteo Salvini, emboldened by his party's strong EU election showing, has stepped up promises to slash taxes and is calling for new EU budget rules, raising fears his plans will drive up Italy's huge public debt.
Italian 10-year bond yields rose for the third day in a row to 2.73%.
Onuekwusi, however, prefers Italian bonds over their negative-yielding German counterparts, arguing the EU was unlikely to impose too severe a punishment.
"If you look at Europe's political landscape, the last thing the (EU authorities) would want to do is to stir up any more negative EU sentiment," he said.
Currency activity was muted, with the dollar index up at 97.905. The dollar is on track for its fourth straight month of gains, benefiting from flows away from markets such as Asia that are considered at greater risk from trade wars.
The euro was unchanged at $.1.1159 after falling two straight days. The British pound held at $1.2656.
Commodity markets were also dominated by fears of a global economic downturn. Brent crude was off more than 1% at $69.15 per barrel. Gold benefited from the safe-haven bid, rising half a percent to $1.285 an ounce.
(Additional reporting by Swati Pandey in Sydney)