Of all the cases of economic espionage charged by the DOJ's National Security Division since 2012, more than 80% of them implicated China.World Politicsread more
"Whilst there is a big dispute at the moment, I think there's also potential for resolution," UBS chairman Axel Weber says of the U.S.-China trade negotiations.World Economyread more
Cryptocurrency fans will hope the futures contracts, which are federally regulated, can provide some much-needed legitimacy to bitcoin.Cryptocurrencyread more
Despite mixed fan and critic reactions to the final season of "Game of Thrones," the eight-season epic took home the top prize in the drama category at the Emmy Awards on...Entertainmentread more
There are alternative financial centers and investors can turn to Singapore, Tokyo or Shanghai if Hong Kong doesn't "shape up," says the founder and chairman of Citic Capital.Asia Economyread more
The Kingdom and oil and gas industry have been slow to shore up defenses, raising red flags about the possibility of longer term fall-out in the region.Technologyread more
Tensions between South Korea and Japan may ultimately disrupt the high-end tech sectors, says Heenam Choi, CEO at South Korea's sovereign wealth fund.Traderead more
On Sunday, the 71st Primetime Emmy Awards honored the best comedies, dramas, limited and variety series from the last year.Entertainmentread more
U.S. President Donald Trump's national security advisor said on Sunday that White House Asia policy adviser Matt Pottinger would become his top deputy.Politicsread more
Removing Neumann is a difficult decision for Son, who has long believed in WeWork and Neumann's vision to quickly expand the company.Technologyread more
Datadog went public on Thursday and instantly hit a $10 billion valuation, becoming the fourth cloud software debut to reach that level this year.Technologyread more
bladder cancer study@
June 3 (Reuters) - An experimental drug developed by Seattle Genetics Inc and Astellas Pharma Inc led to significant, rapid tumor shrinkage in patients with advanced bladder cancer who had been previously treated with immunotherapy and chemotherapy in a midstage trial, according to data presented on Monday.
In the 125-patient study of the drug, enfortumab vedotin, the overall response rate was 44%, meaning tumors were at least 30% smaller for those patients. That included a complete response, or no detectable cancer, for 12% of patients.
Responses were similar even among patients with the worst prognosis, including those whose cancer had spread to the liver, patients who had received three or more previous therapies and those who did not respond to treatment with an immuno-oncology drug, such as Merck & Co's Keytruda, researchers reported.
Current treatment options for those patients are extremely limited.
These data have the potential to change the treatment course of advanced urothelial (bladder) cancer, and it is gratifying to see these results for patients, Dr. Daniel Petrylak of the Yale Cancer Center, who led the study, said in a statement.
Enfortumab vedotin is a new type of treatment called an antibody-drug conjugate. It combines an antibody that targets a specific protein on the surface of tumor cells with a payload of chemotherapy that penetrates and kills cancer cells.
"Basically, it's a smart bomb," said Petrylak, who presented the data at the American Society of Clinical Oncology meeting in Chicago.
The companies, which share development costs and eventual profits, believe the data to be strong enough to seek accelerated approval with U.S. regulators this year.
They are enrolling patients for a confirmatory late-stage trial testing the drug against standard chemotherapy.
"Our priority is to focus on areas with high unmet need and pursue targeted therapies for hard-to-treat cancers where few therapies exist," Andrew Krivoshik, head of oncology for Japan-based Astellas said in a phone interview.
For Seattle Genetics, which received its first approval for a drug to treat lymphoma last year, enfortumab vedotin's approval would expand its portfolio into solid tumor cancers.
In addition to presenting tumor response data - the primary goal of the trial - researchers said most responses occurred within the first cycle of treatment and reported an overall duration of response of 7.6 months.
While the trial was not designed to demonstrate a statistically significant benefit on overall survival, half the patients were still alive after 11.7 months. Typical median overall survival for metastatic bladder cancer is about 9 months.
Researchers were particularly encouraged by the significant tumor shrinkage seen in 38% of patients whose bladder cancer had spread to the liver, as they tend to be among the most difficult to treat with a very poor prognosis.
The American Cancer Society estimates 17,670 people will die from bladder cancer in the United States this year. (Reporting by Tamara Mathias in Bengaluru; editing by Bill Berkrot)