Drone strikes attacked an oil processing facility at Abqaiq and the nearby Khurais oil field on Saturday.Marketsread more
The trucking industry is worth hundreds of billions of dollars per year. Uber is going after this market with Uber Freight, an online platform that matches truckers with...Technologyread more
Trump said oil would be released if needed to keep the market well supplied and he would expedite the approval of pipelines in Texas and other states.Marketsread more
Saudi Aramco is aiming to restore by Monday about a third of its crude output that was disrupted after drone attacks on two key oil facilities, The Wall Street Journal...Marketsread more
Apple's new iPhones can still send texts, download apps, and make video calls, but the company spends a lot of time and effort marketing its new phones as powerful photography...Technologyread more
Some U.S. manufacturers say tariffs, if targeted, will help address longstanding unfair trade practices like intellectual property theft.Traderead more
Supporters of a $15 minimum wage ballot initiative in Florida argue the state's inflation-tied pay hikes have not gone far enough.2020 Electionsread more
Saudi Arabia shut down half its oil production Saturday after drone strikes hit the world's largest oil processing facility in an attack claimed by Yemen's Houthi rebels.Politicsread more
Trusii's hydrogen water machines were supposed to help users with their health problems, but customers claim the company is involved in a giant scam.Technologyread more
The decoupling of the world's two weightiest economies seems as inescapable as its extent and global impact remains incalculable.Politicsread more
BlackBerry has reinvented itself to become a leader in securing mobile communications and in embedded communications. Next year it plans to roll out new products. CEO John...Evolveread more
Sept 9 (Reuters) - Eli Lilly and Co's LOXO-292, a experimental cancer drug the company acquired in January as part of its $8 billion takeover of Loxo Oncology, shrank tumors in nearly 70% of advanced lung cancer patients whose tumors carried specific abnormalities in the RET gene.
The results, presented on Monday at the World Lung Conference on Lung Cancer in Barcelona, will support Lilly's application for U.S. Food and Drug Administration approval later this year.
"At the beginning of this year, we put a bet on Loxo," Dr. Daniel Skovronsky, Lilly's chief scientific officer, said in a telephone interview. "The result today certainly validates that bet and exceeds what many people expected."
Lilly's drug, now called selpercatinib, is intended for patients with rare RET abnormalities, which occur in about 2% of non-small cell lung cancers, some 10 to 20% of papillary thyroid cancers and about 60% of medullary thyroid cancers.
The study released on Monday included the first 105 patients with RET-fusion positive non-small cell lung cancers who had been previously treated with chemotherapy. Many had tried and failed to respond to several other treatments as well.
As of the cut-off date of June 17, 2019, 68% of treated patients had significant tumor shrinkage of 30% or more. In 11 patients whose cancers had spread to the brain, 91% saw significant tumor shrinkage of 30% or more.
In a safety analysis of the whole study population of 531 individuals, nine patients, or 1.7%, stopped the treatment because of drug-related side effects. The most common side effects were dry mouth, diarrhea, high blood pressure, increased liver enzymes, fatigue, constipation and headache.
The company also released preliminary data on 34 patients with RET-fusion positive lung cancer patients who had received no prior treatment. In this group, which has only been followed for about four months, 85% saw significant tumor shrinkage.
Lilly plans to present data on patients with two kinds of thyroid cancers that carry RET alterations at the European Society for Medical Oncology meeting in Barcelona later this month. The company will file for FDA-approval of the drug in all three indications by the end of this year.
Blueprint Medicines is also developing a lung cancer drug targeting RET alterations called BLU-677 and plans to file for FDA approval in the first quarter of 2020. (Reporting by Julie Steenhuysen Editing by Tom Brown)