The Dow fell 77.91 points, or 0.30%, to close at 25,734.97. The S&P 500 advanced 0.50% to 3,115.86. The Nasdaq Composite gained 0.95% to end the day at 10,164.63. Stocks traded higher for most of the session amid positive news on a potential coronavirus vaccine.
A study of a coronavirus vaccine candidate being developed by Pfizer and BioNTech showed the drug created neutralizing antibodies. The results were released online, but have not been reviewed by a medical journal yet. The company also said that, if the vaccine gets regulatory approval, it expects to make up to 100 million doses by year-end and "potentially" more than 1.2 billion by the end of 2021.
The U.S. government's monthly jobs report is set for release Thursday.
Subscribe to CNBC PRO for exclusive insights and analysis, and live business day programming from around the world.