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Coronavirus updates: U.S. death toll tops 250,000; NYC to close schools for in-person learning

The coverage on this live blog has ended — but for up-to-the-minute coverage on the coronavirus, visit the live blog from CNBC's U.S. team.

Stocks are again set to rise on promising Covid vaccine news. Pfizer announced early Wednesday that final data analysis shows its vaccine candidate is 95% effective — better than the previously reported effectiveness of "more than 90%." The company also said the drug worked consistently across all ages, races and ethnicities. Dow Jones Industrial Average futures rose in early trading Wednesday.

Here are some of today's biggest developments:

The following data was compiled by Johns Hopkins University:

  • Global cases: More than 56.2 million
  • Global deaths: At least 1.34 million
  • U.S. cases: More than 11.52 million
  • U.S. deaths: At least 250,485